Children With Birth Defects At Increased Risk for Cancer


The Cancer Predisposition Program at St. Louis Children’s Hospital, led by Dr. Todd Druley, has published a systematic review finding that pediatric cancer risk increases in association with birth defects. Notably, there is a strong, consistent association with CNS abnormalities and the incidence of CNS cancers. With novel high-throughput technologies, we may be able to find the genetic overlap between development and malignancy which will allow for identification of high risk populations among children with congenital abnormalities.

Find the full article in PLoS One.